(Scorpion, Pandinus imperator)
4343-s 0.1 mg | 195.00 EUR
Gly – Asp – Cys – Leu – Pro – His – Leu – Lys – Arg – Cys – Lys – Ala – Asp – Asn – Asp – Cys – Cys – Gly – Lys – Lys – Cys – Lys – Arg – Arg – Gly – Thr – Asn – Ala – Glu – Lys – Arg – Cys – Arg
Synthetic Product (disulfide bonds between Cys3-Cys17, Cys10-Cys21 and Cys16-Cys32)
The purity of Imperatoxin A is guaranteed to be higher than 99% by HPLC
Activator of Ca2+ Release Channels / Ryanodine Receptors
Imperatoxin A is a 33 residue peptide toxin originally isolated from the venom of Scorpion, Pandinus imperator. IpTXa is a potent modifier for the RyR1 and RyR3 channels with high affinity. Imperatoxin A enhances calcium release and is a strong agonist of ryanodine receptors.
Shipping | Storage | Stability
Our product Imperatoxin A (IpTXa) will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.
- H.H. Valdivia, M.S. Kirby, W.J. Lederer and R.Coronado, Proc. Natl. Acad. Sci. USA, 89, 12185 (1992) (Pharmacol.)
- R. El-Hayek, A.J. Lokuta, C. Arévalo and H.H. Valdivia, J. Biol. Chem., 270, 28692 (1995) (Pharmacol)
- F.Z. Zamudio, G.B. Gurrola, C. Arévalo, R. Sreekumar, J.W. Walker, H.H. Valdivia and L.D. Possani, FEBS Lett., 405, 385 (1997) (Original; Structure)
- K. Takeuchi, J.I. Kim, H. Takahashi, K. Sato and I. Shimada, Peptide Science 1999, 307, (2000) (S-S Bond)