Liver-Expressed Antimicrobial Peptide 2 (Human)
LEAP-2 (Human)
Prepro LEAP-2 (Human, 38-77)

4405-s 0.1 mg | 180.00 EUR

Met – Thr – Pro – Phe – Trp – Arg – Gly – Val – Ser – Leu – Arg – Pro – Ile – Gly – Ala – Ser – Cys – Arg – Asp – Asp – Ser – Glu – Cys – Ile – Thr – Arg – Leu – Cys – Arg – Lys – Arg – Arg – Cys – Ser – Leu – Ser – Val – Ala – Gln – Glu

Synthetic Product (disulfide bonds between Cys¹⁷-Cys²⁸ and Cys²³-Cys³³

The purity is guaranteed to be higher than 99% by HPLC

Antimicrobial Peptide in Human Blood Ultrafiltrate

Liver-Expressed Antimicrobial Peptide 2 (Human) LEAP-2 [prepro LEAP-2 (38-77)] exerts antibacterial activities against Gram-positive, Gram-negative bacteria, and yeast (IC50 value was around 5 µM against Saccharomyces. cerevisiae). Interestingly, the amino-terminally truncated form, prepro-LEAP-2 (44-77), has not affected the viability of the germs tested. This 40 amino acid residue peptide, LEAP-2, has been reported to be circulating in human blood. LEAP-2 should prove to be variable in studying its role in self-defense in humans, as well as its role as an antibacterial peptide in the family of the well-established α-/β-defensin.

Shipping | Storage | Stability
Our product LEAP-2 will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

1. A. Krause, R. Sillard, B. Kleemeier, E. Klüver, E. Maronde, J.R. Conejo-García, W.G. Forssmann, P. Schulz-Knappe, M.C. Nehls, F. Wattler, S. Wattler and K. Adermann, Protein Sci., 12, 143 (2003) (Original; S-S Bond: LEAP-2)