Z-VAD-FMK

84,00 € excl. 19% VAT

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SKU: 3188-v Category: Tags: , ,

Z-VAD-FMK | Z-Val-Ala-Asp(OMe)-CH2F
synonym: Z-VAD(OMe)-FMK

3188-v 1 mg | 84.00 EUR

Carbobenzoxy- L-valyl- L-alanyl- β-Methyl- L-aspart-1-yl- Fluoromethane

(M.W. 467.49) C22H30N3O7F

Synthetic Product

Inhibitor for Caspases

Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell permeable, non seletive inhibitor for caspases. The benzyloxycarbonyl protected tripeptide is commonly used as inhibitor for T cell apoptosis. Chemically manufactured Z-VAD-FMK is soluble in DMSO and other organic solvents, but insoluble in water.

Z-VAD-FMK blocks caspases irreversible, but less selective, where as our inhibitor Ac-YVAD-CMK is specific for Caspase-1. We offer additionally the reversible Caspase-1 inhibitor Ac-YVAD-CHO

Shipping | Storage | Stability
Our product Z-VAD-FMK will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

  1. E.A. Slee, H. Zhu, S.C. Chow, M. MacFarlane, D.W. Nicholson and G.M. Cohen, Biochem. J., 315, 21 (1996)
  2. H. Zhu, H.O. Fearnhead, and G.M. Cohen, FEBS Lett., 3740, 303 (1995)

Links to publications that use our caspase specific inhibitor Z-VAD-FMK | code 3188-v:

  1. Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner
  2. Inhibition of UV-C Light–Induced Apoptosis in Liver Cells by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
  3. Determinants of acute and chronic renal allograft injury
  4. Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner

Caspase-1 substrate Ac-YVAD-AMC and Caspase-2 substrate Ac-VDVAD-AMC with the VAD Sequence are available for prompt delivery.

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